Trulicity Insulin Injectable Pens
TRULICITY Insulin helps improve glycemic control in adults with type 2 diabetes with alteration to diet and exercise. Glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists GLP-1-RA) or incretin mimetics are agonists of the GLP-1 receptor. GPL-1-RA is used for the treatment of type 2 diabetes. GPL-1 has the advantage of lowering the risk of hypoglycemia. GLP-1 could be a short-action or long-action medication, depending on its composition. TRULICITY is used to improve glycemic control in adults with type 2 diabetes mellitus, along with alteration to diet and exercise. It also reduces the risk of major adverse cardiovascular events in adults who have type 2 diabetes mellitus and are at risk of cardiovascular disease. Do not use Trulicity Insulin for the treatment of Type 1 diabetes. In addition, TRULICITY is not recommended for patients with severe gastrointestinal illness.
What is the dosage of Trulicity?
The initial dosage is 0.75 mg, administered through injection subcutaneously in the abdomen, thigh, or upper arm. It is to be administered once weekly at any time of day with or without food. If required, your doctor may increase the dosage, over a period of time, to a maximum dose of 4.5 mg. If you miss the dose for four days, administer the missed dose as soon as possible. But after four days, wait until the next scheduled dose.
Carton comes with Single-Dose Pens containing one of the following dosages:
- 75 mg/0.5 mL solution in a single-dose pen.
- 5 mg/0.5 mL solution in a single-dose pen.
- 3 mg/0.5 mL solution in a single-dose pen.
- 5 mg/0.5 mL solution in a single-dose pen.
How to store Trulicity Pen?
Trulicity pens are single-dose injections and should not be reused. It can be stored in a refrigerator at 36°F to 46°F (2°C to 8°C). You can also keep it at room temperature, not exceeding 86°F (30°C), for 14 days.
- Do not freeze Trulicity insulin. If frozen, discard the Pen.
- Protect the Pen from light and heat.
- If you find the glass part broken or happen to drop the Pen, discard it.
- Keep Trulicity Pen set out of the reach of children.
Warnings and Precautions while using Trulicity Insulin Pen
- Risk of Thyroid C-cell Tumors – Elevated or thyroid nodules.
- Pancreatitis – Acute pancreatitis – discontinue Trulicity 100/3.6 promptly and inform your doctor.
- Hyperglycemia or Hypoglycemia.
- Overdose Due to Medication Errors – check the label before each injection.
- Acute Kidney Injury: Usually in association with nausea, vomiting, diarrhea, or dehydration – contact your doctor immediately.
- Hypersensitivity and Allergic Reactions – Serious reactions, including anaphylactic reactions and angioedema – Contact your doctor and immediately discontinue Trulicity insulin.
- Diabetic Retinopathy – If you see a few specks of blood, or spots, floating in your vision, immediately contact your doctor.
- Acute Gall bladder – diseases such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonists.
- Do not share pens and syringes with others, even if you change the needle.
- Do not reuse needles.
- Visit your doctor regularly.
- Review the remaining amount in the Pen and the amount needed.
- Check the pen expiry date and date when last used.
- Ensure Trulicity Insulin is clear and colorless.
Symptoms of Hypoglycaemia may include:
- dizziness or light-headedness.
- blurred vision.
- anxiety, irritability, or mood changes.
- slurred speech.
- confusion or drowsiness.
- fast heartbeat.
- feeling jittery.
Adverse Reactions of using Trulicity Pen
The most common adverse reactions reported are:
- Increased lipase and upper respiratory tract infection.
- Delay of gastric emptying.
The doctor will adjust the dose based on your metabolic needs, blood glucose monitoring results, glycemic control goal, physical activity, changes in meal patterns, changes in renal or hepatic function, or during acute illness to minimize the risk of hypoglycemia or hyperglycemia.
Foods to Avoid with Trulicity
Avoid fried, greasy, and sugary foods since they might be difficult for your body to digest and are more likely to make you feel sick while using GLP-1 medications. Consume more frequently, smaller meals. Consume bland, lightweight food. Drink beverages that are clear or ice-cold, such as water or unsweetened tea.
Is Trulicity and Ozempic the same?
Trulicity Vs Ozempic: Clients always compare Trulicity with other medicines. Trulicity and Ozempic, both GLP-1 RAs, treat type 2 diabetes. They have similar mechanisms and purposes, however they differ in some aspects. They lower HbA1c, a marker of long-term blood sugar management, in clinical trials.
Trulicity contains dulaglutide. Ozempic has semaglutide. Trulicity and Ozempic reduce blood sugar in type 2 diabetics.
Dosage: Trulicity is a weekly injection pen. Ozempic is also available as a single-dose pen, although it is injected weekly.
Half-life: Ozempic outlasts Trulicity. Ozempic’s prolonged half-life may help it work and allow weekly dosage.
Weight Loss: Ozempic has shown higher weight loss than Trulicity in various clinical trials. This weight loss impact can help overweight or obese type 2 diabetics.
Cardiovascular Outcomes: In clinical trials, Trulicity and Ozempic reduced the risk of major adverse cardiovascular events in type 2 diabetics with a history of cardiovascular disease.
Side Effects: Trulicity and Ozempic may cause nausea, vomiting, and diarrhoea. Some people may tolerate one drug better than the other.
Trulicity and Metformin
Trulicity and metformin treat type 2 diabetes in different ways.
Trulicity is a GLP-1 RA. It mimics GLP-1, a hormone secreted by the intestine in response to eating, and is injected. Trulicity lowers blood sugar via boosting insulin secretion and decreasing liver glucose production. It also slows stomach emptying, reducing post-meal blood sugar rises.
Biguanides include metformin. It’s taken orally. Metformin lowers blood sugar via lowering hepatic glucose production. It also boosts insulin sensitivity, making it more effective at transporting glucose from the bloodstream to cells.
Combination therapy: Type 2 diabetics who need numerous drugs to control their blood sugar may be prescribed Trulicity and also metformin. These two medicines can work together to better manage glucose levels throughout the day.