Saxagliptin – Saxagliptin is an anti-diabetic drug and is a member of the DPP-4 inhibitors drug class.
Metformin – Metformin decreases the amount of sugar your liver produces and is a member of the class of drugs known as biguanides. Metformin helps your cells respond to insulin and reduces the blood sugar your liver makes.
How will Komboglyze help?
Komboglyze is used in the treatment of type 2 diabetes mellitus (who are 18 years of age or older) when combined with a nutritious diet and regular exercise.
Komboglyze is a combination medicine:
- A combination of Saxagliptin and Metformin, or Metformin and another drug.
- Saxagliptin, Metformin, and another sulfonylurea drug.
- Saxagliptin, Metformin, and insulin.
How does Komboglyze work?
Saxagliptin and Metformin, the two prescription diabetes drugs, are combined as Komboglyze.
Saxagliptin – Saxagliptin, also known as dipeptidyl peptidase-4 inhibitors, is a member of a group of medications referred to as DPP-4 inhibitors.
- Saxagliptin aids in lowering blood sugar levels. They assist in blood sugar regulation by preventing the breakdown of hormones related to appetite, eating patterns, and food digestion. The drug prevents the breakdown of these hormones. As a result, your pancreas will produce more insulin.
- Additionally, it reduces pancreatic glucagon synthesis, which would otherwise raise blood sugar levels.
- Saxagliptin reduces blood sugar levels between meals and aids in lowering your body’s production of sugar.
Metformin – Metformin is a member of the biguanide class of anti-diabetic medications. It helps in reducing the amount of sugar your liver produces. It also makes your body more responsive to insulin, which improves your body’s capacity to break down sugar. Metformin primarily lowers high blood sugar by reducing hepatic gluconeogenesis, the medical term for manufacturing sugar in your liver. The rate of hepatic gluconeogenesis is three times higher in type 2 diabetes patients on average, and Metformin treatment helps lower this by more than one-third. In addition, Metformin reduces the creation of liver sugar and improves blood sugar absorption from your GI tract.
How to take Kombogylze?
Always adhere to your doctor’s recommendations. How many tablets you should take and how frequently you should take them will be determined by your doctor. For the most part, Komboglyze is taken twice daily with meals to reduce the stomach discomfort that Metformin may bring.
Dosage of Komboglyze
Your body weight, other medical issues, and other drugs are just a few examples of the many factors that can alter the dosage of medication you need.
Note: Do not alter the medication your doctor has prescribed if you find something different from the ones listed here. It would help if you strictly took this medication as your doctor advised.
The daily dose of Komboglyze is based on body needs, tolerance to side effects, and effective control of your blood sugar levels. Examples of KOMBOGLYZE-supplied tablets containing saxagliptin /metformin hydrochloride are:
Typically, your doctor may add 2.5 mg of Saxagliptin to the current level of Metformin you are already taking. Kombogylze is administered twice daily with meals. If you are switching from taking Saxagliptin and Metformin, your doctor may prescribe the exact dosage of Saxagliptin and Metformin. If you are changing from taking Saxagliptin and Metformin individually, doctors may prescribe the saxagliptin-metformin amount you have been taking. The maximum recommended daily dose is 5mg of Saxagliptin and 2000mg of Metformin.
If you accidentally miss a dosage, take it as soon as you remember with food, then resume your regular dosing plan. However, you should skip the missed dose and continue with your standard dosing plan if you only remember almost the time for your next dose. Never take two doses at once.
Note: Do not alter the medication your doctor has prescribed if you find something different from the ones listed here. You must take this medication strictly as your doctor has advised.
Safeguards and Precautions of Komboglyze
Inform your doctor if you take any of the following medications since they may interact with Komboglyze:
- Other diabetes drugs, such as Glyburide
- Cationic drugs (e.g., digoxin, amiloride, procainamide, morphine, quinine, quinidine, triamterene, ranitidine, vancomycin, and trimethoprim)
- Other drugs may cause hyperglycemia (high blood sugar) and may lead to a loss of blood sugar control.
- ACE inhibitor drugs (may lower blood glucose)
Do not take Komboglyze if you:
- Have metabolic acidosis – Metabolic acidosis is a condition with too much acid in the body fluids. This includes diabetic ketoacidosis or lactic acidosis.
- Currently have or have had a liver or kidney problem.
- Have or have had heart failure or cardiovascular problems (abrupt loss of blood circulation), or cardiorespiratory insufficiency
- Drink excessive amounts of alcohol.
- Are highly stressed, have severe infections/inflammation, are experiencing trauma, are about to have surgery, or during a surgery recovery phase
- Have severe dehydration
- Are currently breastfeeding
- Are pregnant, or are planning to become pregnant
- Are about to receive an injection of dye or contrast agent for an imaging procedure
- Have any allergies to Saxagliptin, Metformin, or any of the ingredients, or if you are allergic to other drugs belonging to the DPP-4 class medicines, you should not use this medication.
Komboglyze Side effects
Metformin, a component of Komboglyze, can potentially lead to lactic acidosis. Lactic acidosis is a life-threatening disorder and is treated in a hospital. Do not consume much alcohol while taking this medication, as it may raise your risk of developing lactic acidosis.
In some cases, the probability of heart failure increases for patients receiving Komboglyze. (When your heart cannot pump enough blood to meet your body’s needs)
Common adverse effects are the following:
- upper respiratory tract infection
- urinary tract infection (UTI)
- upset stomach (gas, abdominal bloating)
- loss of appetite
People taking sulfonylurea medications or receiving insulin treatment are more prone to experience hypoglycemia (low blood sugar levels). Before calling your doctor, check your blood sugar levels and treat them if they are down. Hypoglycemia can cause symptoms like headache, trembling, rapid heartbeat, perspiration, hunger, changes in vision, and mood swings.
Serious adverse effects of Komboglyze may include
- Allergic (hypersensitivity) reactions, symptoms of which include swelling of the lips, face, or throat, difficulties breathing, hives, rash, itching, flaking or peeling skin
- Pancreatitis (inflammation of the pancreas)
- Lactic acidosis (an excess of lactic acid in your blood)
These are not all of the potential adverse effects. If you have any inquiries about side effects, contact your doctor.
Discuss with your doctor any adverse side effect that bothers you or does not go away. For medical advice about side effects, contact your doctor.
Remember that regular physical exercise is crucial to treating diabetes or managing prediabetes, along with your diet planning, weight management, and medications. Because your cells become more responsive to insulin while you are active, your blood glucose, also known as blood sugar, can be lowered more successfully. Take your medications regularly and follow up with your healthcare specialist.