About Jentadueto Tablets?
(See detailed Medicine Prescription Information here)
Linagliptin belongs to the class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which reduce blood sugar levels. I’m a member of the biguanide medication class. Metformin decreases the amount of sugar your liver produces and is a member of the drug family known as biguanides. Metformin helps your cells respond to insulin and reduces the blood sugar your liver makes.
How will Jentadueto help?
The drug works best for treating type 2 diabetes when combined with a nutritious diet and regular exercise.
Jentadueto tablets are prescribed to patients:
- If metformin alone cannot manage blood sugar,.
- You are currently taking Metformin and Linagliptin (Trajenta).
- Those who use a combination drug with sulfonylurea.
How do Jentadueto tablets work?
Linagliptin and metformin are two anti-diabetic medications found in the medicine Jentadueto tablets.
Linagliptin: Linagliptin is a member of a class of drugs known as dipeptidyl peptidase-4 inhibitors, or DPP-4 inhibitors. They aid in blood sugar regulation by preventing the breakdown of hormones related to appetite, eating patterns, and food digestion. In addition, the drug prevents the corrosion of these hormones. As a result, your pancreas will produce more insulin. In addition, lignagliptin reduces the amount of glucagon (which can raise blood sugar levels) produced by the pancreas. The effects of insulin and glucagon gradually diminish as your blood sugar levels normalize. This mechanism prevents hypoglycemia, a significant side effect of many oral hypoglycemic medications.
The primary effects of Jentadueto tablets will include the significant side effects of metformin.
Metformin: Metformin is a member of the biguanide class of anti-diabetic medications. It helps reduce the amount of sugar your liver produces. It also makes your body more responsive to insulin, which improves your body’s capacity to break down sugar. Metformin primarily lowers high blood sugar by reducing hepatic gluconeogenesis, the medical term for manufacturing sugar in your liver. The rate of hepatic gluconeogenesis is three times higher in type 2 diabetes patients on average, and metformin treatment helps to lower this rate by more than one-third. In addition, metformin reduces the creation of liver sugar and improves blood sugar absorption from your GI tract.
Before taking Jentadueto tablets
Before starting this medication, your doctor should evaluate your kidney function for the estimated glomerular filtration rate (eGFR). You should take Jentadueto tablets once a day with a meal or as directed by your health care provider. Make sure to swallow the Jentadueto tablets completely. Avoid breaking, crushing, dissolving, or chewing the tablet.
What is the dosage of Jentadueto?
The typical dose for an adult is 2.5 mg of Linagliptin and 500 mg of Metformin, or 2.5/850 mg, or 2.5/1000 mg, taken twice a day with food. For a reduced risk of stomach discomfort, take the Jentadueto tablet with meals. Make sure to stay within the combined daily dose of 2000 mg of metformin and 5 mg of linagliptin.
Note: Do not alter the medication your doctor has prescribed if you find something different from the ones listed here. It would help if you strictly took this medication as your doctor advised.
Warnings and Precautions while using Jentadueto
You should not take this medication if you:
- Are you allergic to Linagliptin, Metformin, or any of the other non-medicinal ingredients?
- Have type 1 diabetes (in this case, your body does not produce any insulin).
- Currently, I have or have had liver or kidney problems.
- Are affected by lactic acidosis (a condition in which there’s too much acid in the body).
- Have metabolic acidosis (it relates to a buildup of acid in the body due to kidney disease or kidney failure) or diabetic ketoacidosis (increased ketones in the blood or urine).
- Have upcoming x-ray tests that require the injection of dyes or contrast agents.
- Are highly stressed, have severe infections, are experiencing trauma, are before surgery, or have recently had surgery.
- Have cardiovascular collapse (abrupt failure of blood circulation) or cardiorespiratory insufficiency.
- Are dehydrated (a reduction in the amount of body fluids). Dehydration can happen if you are sick with a fever, vomiting, or diarrhea, sweat a lot with activity or exercise, and do not drink enough fluids.
- Drink a lot of alcohol, regularly or occasionally (such as in binge drinking).
- Are breastfeeding
- Are pregnant, or are you planning on becoming pregnant?
Jentadueto side effects
In rare cases, it has induced lactic acidosis, which has led to death, hypothermia, hypotension, and refractory bradyarrhythmias (slow heart rate (bradycardia) and irregular heart rhythm (arrhythmia)).
Lactic acidosis symptoms include feeling sick, myalgias (muscle soreness), somnolence (drowsiness), respiratory difficulties, and abdominal pain.
Risk factors for lactic acidosis include kidney impairment, concurrent drug usage, age greater than 65, imaging investigations including the use of a contrast dye, surgery, and other operations, hypoxic situations, and excessive alcohol consumption.
Common adverse effects may include:
- Nasopharyngitis is characterized by a stuffy or runny nose and a sore throat.
- Symptoms include diarrhea, nausea, stomach upset, bloating, and flatulence.
Less common side effects may include:
- Allergic reactions can manifest as hives, rash, swelling of the lips, face, and throat, along with symptoms such as coughing, wheezing, or shortness of breath.
- Pancreatitis (inflammation of the pancreas)
- A buildup of lactic acid in the blood—lactic acidosis—can be fatal.
- Reduced blood sugar (hypoglycemia)
- Mouth ulcer
You have an increased chance of developing low blood sugar if you use Jentadueto tablets and pharmaceuticals like sulfonylureas. Call your doctor immediately if you experience any signs of low blood sugar. Check your blood sugar levels first, then treat them and call your doctor.
Symptoms of hypoglycemia (low blood sugar): shaking, sweat, a quick heartbeat, changes in vision, hunger, headaches, and mood.
