HUMALOG is a rapid-acting human insulin analog indicated. It improves glycemic control in adults and children with diabetes mellitus. You can deliver your insulin dosages more conveniently with the KwikPen, a disposable, pre-filled mealtime insulin pen. A pen is a handy tool that lets you administer your dose subcutaneously (under the skin) without needing a vial, needle, or syringe. After first-time usage, the pen can be stored without refrigeration below 86°F (30°C) and must be used within 28 days or discarded, even if it still contains Humalog.

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What exactly is Humalog?

Insulin medication used to treat diabetes is marketed under the brand name Humalog. The Humalog KwikPen and vials are already pre-filled with Humalog Insulin Lispro, a synthetic insulin analog that functions similarly to natural insulin. Close to the stomach, the pancreas contains beta cells that produce the hormone insulin. Insulin regulates the breakdown of food (sugars, lipids, and proteins) for digestion. Insulin also facilitates the absorption of sugar into fat, liver, and skeletal muscle cells from the circulation.

It is a rapid-acting insulin analog, meaning it is designed to help regulate blood sugar levels in diabetics shortly after injection. With the small dimensions and straightforward design of the Humalog KwikPen, you can precisely, conveniently, and on-the-go regulate your blood sugar levels at home or on the road.Diabetes patients typically use Humalog to control elevated blood sugar levels. It is prescribed to people with type 1 diabetes who do not produce insulin, as well as those with type 2 diabetes who may not produce enough insulin or use it effectively.

How does Humalog function?

Humalog, which contains the active constituent insulin lispro, assists diabetics in regulating and controlling their blood sugar (glucose) levels. In the absence of diabetes, the pancreas secretes insulin in response to rising blood sugar levels, particularly after a meal. Humalog is intended to replicate the rapid action of insulin produced naturally by the pancreas.

After injecting Humalog, the drug begins to work very rapidly, typically within 15 minutes. This rapid onset is crucial for managing post-meal blood sugar increases.
Humalog’s principal function is to facilitate glucose uptake by cells throughout the body. When Humalog enters the bloodstream, it functions as a signal to cells, instructing them to allow glucose entry by opening their membranes. This decreases the glucose concentration in the circulation.In contrast to other types of insulin with a prolonged duration of action, the effects of Humalog are relatively short-lived. It is typically active for two to four hours. This brief duration enables a more precise regulation of blood sugar levels, particularly around meals. Due to Humalog’s swift action, it is frequently used as a mealtime insulin. People with diabetes inject Humalog briefly before or after meals to counteract the rise in blood sugar that results from eating.

The Combination of Medical Treatment

Insulin can interact with the human organism in two ways: bolus and basal. Bolus insulin is a rapid-acting insulin administered prior to meals. Due to glucose increases immediately following meals, it helps the body maintain glucose control. Bolus insulin is referred to as “rapid-acting” insulin because it must act rapidly. It begins to work in about 15 minutes, reaches its zenith in about an hour, and continues to work for two to four hours.

Basal insulin is longer-acting and aids in the steady secretion of insulin throughout the day. As blood glucose levels rise, basal medication will release more insulin into the blood, while insulin release will decrease as the body’s demand for insulin decreases. In certain instances, diabetics may combine Humalog with a basal insulin (such as insulin glargine or insulin detemir). Basal insulin provides a constant level of insulin throughout the day and night, whereas Humalog is used to treat meal-induced blood sugar spikes. Insulin detemir (Levemir) and insulin glargine (Lantus) are examples of basal insulins.

Individuals with type 2 diabetes frequently combine Humalog with oral diabetes medications. Metformin, sulfonylureas, DPP-4 inhibitors, and SGLT-2 inhibitors are common oral medications. These medications function in various methods to reduce blood sugar levels. Combining them with Humalog can improve glucose control overall.

Some people with type 2 diabetes combine Humalog with GLP-1 receptor agonists, such as liraglutide (Victoza) or dulaglutide (Trulicity). GLP-1 receptor agonists stimulate insulin release and reduce glucagon secretion in response to elevated blood sugar levels. This combination can provide effective blood sugar control with fewer hypoglycemic episodes and benefits for weight management.

Diabetes is frequently accompanied by conditions such as elevated blood pressure and cholesterol. ACE inhibitors, statins, or beta-blockers may be prescribed alongside Humalog, particularly if these conditions are prevalent comorbidities in the individual.

Individuals with diabetes who are at risk for cardiovascular events may be prescribed aspirin. It is used to reduce the risk of blood clotting and cardiovascular complications; it does not lower blood sugar.

To ensure the efficacy and safety of your treatment plan, you must always adhere to your doctor’s instructions and monitor your blood sugar levels on a regular basis when combining medications. In addition, inform your healthcare provider of all medications you are taking, including over-the-counter medicines and dietary supplements, in order to avoid potential drug interactions.

Warnings and Precautions of Humalog Insulin Lispro

Even if you change the needle, do not share your Humalog Insulin Lispro vials. Syringes will not accurately measure insulin in units per mL. A severe overdose might follow, resulting in dangerously low blood sugar levels that could endanger your life. Also, if you’re blind or visually challenged, you shouldn’t use Humalog without a trained user’s assistance.

Before you use your Humalog Insulin Lispro Kwikpen and Humalog Insulin Lispro Cartridges, talk to your doctor or pharmacist if:

  • You now have or previously had liver or kidney issues.
  • You start working out more often than usual.
  • You wish to alter your regular diet.
  • You consume alcohol.
  • You’re crossing more than two time zones.
  • You’re ill
  • You are expecting a child or intend to have a child.
  • You take vitamins or other medications.

Humalog Insulin Lispro Vials Side Effects

Common adverse effects may include:

  • Hypoglycemia
  • Injection site reaction

Less common adverse effects may include:

  • Diabetic Acidosis
  • Lipoatrophy
  • Hypokalemia

The most frequently reported side effect of Insulin Lispro is low blood sugar, or hypoglycemia.

Symptoms of hypoglycemia may include:
  • fast heartbeat,
  • excessive hunger,
  • headache,
  • nausea,
  • dizziness,
  • confusion,
  • weakness,
  • blurred vision ,
  • tremor,
  • drowsiness,
  • sweating,
  • trouble concentrating,
  • seizure (convulsions).

It is common to experience localized allergic skin rashes. You may have swelling, redness, and itching where you got your injection. Factors like impurities in the skin cleansing solution or your injection technique may cause these rashes.

It is common to experience localized allergic skin rashes. You may have swelling, redness, and itching where you got your injection. Factors like impurities in the skin cleansing solution or your injection technique may cause these rashes.

Insufficient insulin levels can cause diabetic acidosis, which could happen if you do not remember to take your insulin, take less than your doctor has suggested, overeat, get sick, or forget to take it altogether. The first signs usually appear gradually over hours or days and include feeling tired, thirsty, flushed, and lacking appetite. More severe symptoms include a quickened heartbeat and heavy breathing. Without treatment, it may cause a coma, loss of consciousness, or even death. You must get medical attention immediately if you encounter any of these symptoms.

Rarely, the subcutaneous injection of insulin can cause either lipohypertrophy, or the growth or thickening of tissue, or lipoatrophy, which is a depression in your skin. Contact your doctor immediately if you detect any changes at or near the injection site for any of these problems.

Other less commonly reported side effects can include hypokalemia due to reduced blood potassium (K+) levels. More severe side effects can include anaphylaxis, a serious allergic reaction, and other hypersensitivities or allergic reactions.

In summary, humalog is a rapid-acting insulin analog that lowers blood sugar by replicating the actions of natural insulin. It is a useful instrument in the management of diabetes, especially for controlling post-meal glucose levels and preventing hyperglycemia (high blood sugar) in diabetic patients.

The precise dosing and timing of Humalog are tailored to the specific requirements and circumstances of each individual. When using Humalog, it is essential to monitor your blood sugar levels frequently to ensure that your dosage and scheduling are appropriate. This permits adjustments to your treatment plan to be made as necessary. Always adhere to your healthcare provider’s instructions for the safe and effective administration of Humalog.

Buy Humalog insulin in four different forms:

  • HUMALOG – insulin lispro injection, solution.
  • HUMALOG KWIKPEN – insulin lispro injection, solution.
  • HUMALOG JUNIOR KWIKPEN – insulin lispro injection, solution.
  • HUMALOG TEMPO PEN – insulin lispro injection, solution.

The different packages are: